Actin filaments connect myosin nodes together to form a network during contractile-ring formation in cells expressing GFP-CHD(Calponin Homology Domain of IQGAP Rng2p) and myosin light chain Rlc1p-mRFP1. |
The assembly of the contractile ring in fission yeast cells expressing GFP-tagged Myo2p and a Spindle Pole Body (SPB, an equivalent of the centrosome) marker Sad1p-GFP. The small dots are Myo2p nodes and the bright spots are SPBs. |
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The long-term goal of our laboratory is to understand the roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal and cancer cells. In the near term, I am focusing on the molecular mechanisms of cytokinesis in the fission yeast S. pombe using a combination of cellular, molecular, biochemical, genetic, and microscopic approaches. |
